MODELING OF CARBONIC ANHYDRASE (II) INHIBITORY ACTIVITIES OF SULPHONILAMIDE SCHIFF BASES BY ARTIFICIAL NEURAL NETWORK TRAINED WITH DIFFERENT NUMERICAL TECHNIQUES

Objective: The aim of the present study was to develop robust linear and non-linear Quantitative Structure-Activity Relationship (QSAR) models for exploring the relationship between the structural features of a series of sulphanilamide Schiff bases and their CA (II) inhibition activities.Methods: QSAR modeling of carbonic anhydrase (II) inhibiting activities of a series of sulphanilamide Schiff bases as a function of theoretically derived molecular descriptors calculated by Dragon software was established linearly by stepwise multiple linear regression (SW-MLR) method and non-linearly by artificial neural network (ANN) method, trained with different numerical techniques namely, Scaled conjugate gradient (SCG), quasi-Newton (BFGS), and Levenberg-Marquardt (LM) algorithm. SW-MLR method was also used to select descriptors from large descriptor pool. After the selection of variables, best selected linear model was validated by Y-randomization test. The applicability domain was assessed by the normalized mean Euclidean distance value for each compound. The prediction quality of proposed non-linear QSAR models was tested externally using validation and test set.Results: The low value of R2average = 0.214 from the Y-randomization test and no significant correlation between the selected descriptors indicates that linear model is reliable, and robust. Applicability domain analysis has also revealed that the suggested model has acceptable predictability. To explore non-linear relationship between selected descriptors and the target property, ANN approach trained with three supervised algorithms (BFGS, SCG and LM) was used. Statistical comparison of the quality of models obtained using ANN method trained with above mentioned three algorithms with SW-MLR model shows that ANN with 4-3-1 architecture and trained with LM algorithm has better predictive power as indicated by low RMSEval (0.11), MAPEval (11.95) values and high R2val (0.96) value.Conclusion: The results of this work indicated the ANN trained with fastest Levenberg-Marqardt algorithm is a promising tool for establishing non-linear relationship between selected sulphanilamide Schiffbases and their CA (II) inhibition values

Choroidal osteoma with CNVM – Successful treatment with intravitreal Bevacizumab

AbstractTwenty-seven years old healthy woman presented with complaints of sudden painless blurred vision in right eye for 1week. On examination, visual acuity was 20/30 in the right eye and 20/20 in left eye. Fundus examination OS was normal; OD demonstrated a flat, opaque, yellowish parapapillary choroidal lesion with grayish membrane associated with minimal subretinal fluid suggestive of a CNVM in the center. B-scan ultrasonography revealed findings consistent with a choroidal osteoma. Fundus fluorescein angiography of the right eye revealed a relatively well-defined area of hyperfluorescence that increased in size and intensity in the later phases suggestive of active extrafoveal CNVM. Optical coherence tomography confirmed the extrafoveal CNVM with subfoveal fluid. She was treated with intravitreal Bevacizumab OD. At the 2weeks visit, vision OD improved to 20/20. The FFA and OCT revealed a resolved CNVM. Intravitreal Bevacizumab may be an effective alternative in the management of CNVM secondary to choroidal osteoma

IMPACT OF TANNERIES ON GROUND WATER CONTAMINATION IN UNNAO DISTRICT

Attempt is made to understand the impact of tanneries on ground water quality of Unnao. Study was undertaken to evaluate physico-chemical parameters and chromium, lead iron concentration in ground water near tannery industries. The results revealed that only two parameters fluoride and chromium are present in slight high concentration than permissible limit. Ground water quality % sample compliance / violation with respect to BIS standard were also studied

Role of DIBER DRDO Technologies in Improving Livelihood Opportunities and Curtailing Migration in Uttarakhand

Migration of local population of Uttarakhand (UK) border areas is presently serious issues for national security since; this State is sharing international border (~650 km) with China/Tibet and Nepal. Among the various factors reported for migration, few notables are search for better livelihood, unemployment, difficult remote terrain and poor land connectivity, less productivity from agriculture due to abiotic and biotic stresses etc. Hence, measures to increase the livelihood opportunities in these border areas to curb the problem of migration through intervention of modern agro-animal technologies are essentially required. In this attempt, Defence Institute of Bio Energy Research (DIBER) has already developed various agro-animal mature technologies, in terms of high yielding and genuine quality seed/seedlings, protected cultivation technology, soil-less cultivation technology, angora farming, mushroom cultivation, medicinal and aromatic plants (MAPs) cultivation technology, hydro-fodder, etc that shown great promise and impact in increasing the farm income and livelihood opportunities for civil inhabitants of these marginal regions. This article highlights the DIBER outreach extension efforts for ensuring better livelihood opportunities to farmers of border area and also to curtail migration that will in turn increase strategic support to Army and paramilitary defence forces deployed in three border Distts (Uttarkashi, Chamoli and Pithoragarh) of UK

Incidence of HIV infection in eastern Uttar Pradesh: HIV counseling and testing services record based retrospective study

Background: India has approximately 2.4 million of people living with HIV and out of these two thirds live in rural areas. This study may yield significant data to understand epidemiology of HIV/AIDS in this region that would help in designing techniques for effective implementation to prevent this infection.Methods: The present study was a comprehensive retrospective hospital-based investigation of the HIV infection in eastern Uttar Pradesh, India based on a large number of clinical samples at HCTS centre, representing different geographic regions and has been functional since 2002, conducting HIV tests, counselling of patients as well as maintains proper records.Results: A total of 444 HIV positive clients were registered in this retrospective study. The male and female ratio among all positive clients was 1.67:1 and the most common age group for both the genders was 35-49 years. Among 444 HIV positive clients, HIV-TB co-infection found in 72 (16.21%) cases. Out of 444 clients, 177 (40%) and 167 (38%) found extremely immunocompromised with low CD4 cells count in range between of 0-100 cells/mm3 and >100-350 cells/mm3 respectively. Mortality was seen in 72 (16%) out of 444 HIV positive clients.Conclusions: There is an urgent need of information, education about this disease and by providing suitable occupation or to make them aware, which will markedly help in preventing the spread of HIV pandemic in this geographical region

Utjecaj fluorida proizvedenih aluminijskim industrijskim postrojenjem na biljke i područja nastanjena ljudima

Fluorine is a highly reactive common element that does not occur in nature in the elemental state. It exists in the form of fluorides and accounts for about 0.3 g/kg of the Earth’s crust. Generally, it is found in the form of a number of minerals like fluorspar, cryolite and fluor-apatite. Fluoride has both positive and negative effects on individual health. Fluoride, in the form of fluorspar and cryo- lite is distributed extensively in the lithosphere, and is renowned as the thir- teenth most common among elements in the earth’s crust. Hydrogen fluorides in gaseous form accumulate in the leaves of generally sensitive plants against a concentration gradient and therefore, considered as a most phytotoxic air pollut- ant and affects plants at extremely low concentration. As per our study, it is found that the fluoride impacts on fauna are in normal condition, but in coming times it may have adverse impact on fauna and flora of surroundings of Hindalco Industries Limited.Fluor je vrlo reaktivan element koji se u elementarnom obliku ne pojavljuje u prirodi. Postoji u obliku fluorida u zemljinoj kori, gdje se nalazi u omjeru od oko 0,3 g/kg. Općenito, nalazi se u obliku velikog broja minerala poput fluorita, kriolita i apatita. Fluorid ima i pozitivne i negativne učinke na ljudsko zdravlje. Fluorid, u obliku fluorita i kriolita, široko je rasprostranjen u litosferi, a poznat je i kao trinaesta najčešća tvar u Zemljinoj kori. Fluorovodici u plinovitom obliku nagomilavaju se u listovima uglavnom osjetljivih biljaka prema gradijentu koncentracije. Stoga se smatraju najfitotoksičnijim onečišćujućim tvarima u zraku, a djeluju na biljke i pri ekstremno niskim koncentracijama. Prema našoj studiji utvrđeno je da su učinci fluorida na faunu u uobičajenim okvirima, ali u budućnosti može imati štetan utjecaj na faunu i floru u okruženju tvornice Hindalco Industries Limited

Utjecaj fluorida proizvedenih aluminijskim industrijskim postrojenjem na biljke i područja nastanjena ljudima

Fluorine is a highly reactive common element that does not occur in nature in the elemental state. It exists in the form of fluorides and accounts for about 0.3 g/kg of the Earth’s crust. Generally, it is found in the form of a number of minerals like fluorspar, cryolite and fluor-apatite. Fluoride has both positive and negative effects on individual health. Fluoride, in the form of fluorspar and cryo- lite is distributed extensively in the lithosphere, and is renowned as the thir- teenth most common among elements in the earth’s crust. Hydrogen fluorides in gaseous form accumulate in the leaves of generally sensitive plants against a concentration gradient and therefore, considered as a most phytotoxic air pollut- ant and affects plants at extremely low concentration. As per our study, it is found that the fluoride impacts on fauna are in normal condition, but in coming times it may have adverse impact on fauna and flora of surroundings of Hindalco Industries Limited.Fluor je vrlo reaktivan element koji se u elementarnom obliku ne pojavljuje u prirodi. Postoji u obliku fluorida u zemljinoj kori, gdje se nalazi u omjeru od oko 0,3 g/kg. Općenito, nalazi se u obliku velikog broja minerala poput fluorita, kriolita i apatita. Fluorid ima i pozitivne i negativne učinke na ljudsko zdravlje. Fluorid, u obliku fluorita i kriolita, široko je rasprostranjen u litosferi, a poznat je i kao trinaesta najčešća tvar u Zemljinoj kori. Fluorovodici u plinovitom obliku nagomilavaju se u listovima uglavnom osjetljivih biljaka prema gradijentu koncentracije. Stoga se smatraju najfitotoksičnijim onečišćujućim tvarima u zraku, a djeluju na biljke i pri ekstremno niskim koncentracijama. Prema našoj studiji utvrđeno je da su učinci fluorida na faunu u uobičajenim okvirima, ali u budućnosti može imati štetan utjecaj na faunu i floru u okruženju tvornice Hindalco Industries Limited

A rare case of repeated expulsions of a giant cervical fibroid per vaginum followed by delivery of near term babies in two consecutive pregnancies

Huge cervical fibroid polyp with red degeneration, obstructing birth canal might be a night mare for obstetricians. Most of us will plan for a caesarean section but somehow due to lack medical consultation; a patient in rural setup with a huge cervical fibroid, delivered normal in two consecutive pregnancies. This case is unique because no such case has been reported in literature where normal delivery took place twice in the same patient, with such a huge fibroid with red degeneration, obstructing the birth canal

Advances in Natural Polymeric Nanoparticles for the Drug Delivery

Natural and biodegradable polymers have been the key area for utilizing their advantages which make them a possible option for development of various drug delivery systems. The complexity of diseases and the intrinsic drug toxicity and side effects has led to an interest for development and optimization of drug delivery systems. The advancements in nanotechnology have favored the development of novel formulations which can modulate the biopharmaceutical properties of bioactives and thus improves the pharmacological and therapeutic action. The shape, size, and charge nanoscale delivery system, such as nanoparticles (NPs) are required to be investigated and changed in order to promote and optimize the formulations. The various natural polymeric NPs (PNPs) have been found to be key tool to enhance bioavailability or specific delivery to certain site of action. In this chapter, the uses of various polymeric materials for the development of NPs as drug delivery systems for various ailments have been described. The entrapment of bioactive compounds in PNPs systems is a hopeful move toward improvement of efficacy of drug toward the treatments of various diseases